A mad scientist named Arana is creating giant spiders and dwarves in his lab on Zarpa Mesa in Mexico. He wants to create a master race of superwomen by injecting his female subjects with spider venom.
Mesa of Lost Women is a 1953 American low-budget black-and-white science fiction film directed by Ron Ormond and Herbert Tevos from a screenplay by the latter and Orville H. Hampton.
The film opens with a brief scene serving as its introduction. A man is being caressed by feminine hands. The next shot includes the face of the woman, Tarantella (Tandra Quinn). A brief kiss between her and the man, ends with his lifeless body falling down. A disembodied voice asks the audience "Have you ever been kissed by a girl like this?" [1] The narrative properly begins in a desert. A narrator (Lyle Talbot) mocks the overblown ego of humanity, a race of puny bipeds which claims to own planet Earth and every living thing on it. Yet, they are outnumbered by the insects, and the Hexapods are likely to survive longer that the humans.[1] The narrator then claims that when men or women venture off "the well beaten path of civilization" and deal with the unknown, the price of their survival is the loss of their sanity.
During this narration, the film introduces its protagonists Grant Phillips (Robert Knapp) and Doreen Culbertson (Paula Hill). The narrator explains that the two of them are lost in the "great Mexican desert", the "Muerto desert". They are nearly dead from dehydration and sunburn when discovered by an American surveyor and his Mexican companion. These characters are identified as Frank (John Martin) and Pepe (Chrispin Martin).The two victims of the desert recover their senses in "Amer-Exico Field Hospital", somewhere in Mexico. Grant starts narrating his story to Doc Tucker (Allan Nixon), foreman Dan Mulcahey (Richard Travis), and Pepe.
The film flash-backs to events occurring a year earlier in Zarpa Mesa. Famous scientist Leland Masterson (Harmon Stevens) arrives, having accepted an invitation Dr. Aranya (Jackie Coogan). Aranya has reportedly penned "brilliant" scientific treatises, and Masterson looks forward to meeting him in person. Masterson is genuinely intrigued by Aranya's theories, but his host informs Masterson that his work is not theoretical. He has already completed successful experiments, creating both human-sized tarantula spiders and human women with the abilities and instincts of spiders. His creation Tarantella has regenerative abilities, sufficient to regrow severed limbs. He seriously expects her to have a lifespan of several centuries. His experiments have had less success in male humans, who simply turn to disfigured dwarfs.